Kruppel-like Factors (KLFs) in muscle biology
نویسندگان
چکیده
منابع مشابه
Ascending KLFs in cardiovascular biology.
Cardiac transcription factor biologists have spent many years identifying transcription factors that function as critical regulators of important cellular processes; however, the challenges in understanding cardiac transcriptional regulatory networks have been formidable. The cardiovascular system is a complex organ system in which component muscle cells must interact with other cells in a coor...
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Krüppel-like factor (KLF) family members share a three C2H2 zinc finger DNA binding domain, and are involved in cell proliferation and differentiation control in normal as in pathological situations. Studies over the past several years support a significant role for this family of transcription factors in carcinogenesis. KLFs can both activate and repress genes that participate in cell-cycle re...
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The Krüppel-like factor family of transcription factors plays an important role in differentiation, function, and homeostasis of many cell types. While their role in lymphocytes is still being determined, it is clear that these factors influence processes as varied as lymphocyte quiescence, trafficking, differentiation, and function. This review will present an overview of how these factors ope...
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The ETS (E26 Transformation-specific Sequence) factors are comprised of a family of transcription factors that share a highly conserved DNA binding domain. Although originally described for their role as protooncogenes in the development of several types of human cancer, they have subsequently been shown to regulate a wide variety of biological processes including cellular growth and differenti...
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The association of transcriptional coactivators with DNA-binding proteins provides an efficient mechanism to expand and modulate genetic information encoded within the genome. Myocardin-related transcription factors (MRTFs), including myocardin, MRTF-A/MKL1/MAL, and MRTF-B/MKL2, comprise a family of related transcriptional coactivators that physically associate with the MADS box transcription f...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2007
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2007.04.005